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Oligonucleotide-based PROTACs to Degrade RNA- and DNA-Binding Proteins

基于寡核苷酸的PROTAC降解RNA和DNA结合蛋白

Céline N Weller,Jonathan Hall

Chimia. 2025 Mar 26;79(3):167-171. DOI:10.2533/chimia.2025.167

Towards the Rational Design of Monovalent Degraders: Lessons Learnt from Cyclin K Degraders

单价降解剂的理性设计：从Cyclin K 降解剂中获得的经验

Katie L Thomas,Benjamin R Bellenie,Olivia W Rossanese

Chimia. 2025 Mar 26;79(3):162-166. DOI:10.2533/chimia.2025.162

Challenges and Opportunities in DNA Encoded Library Screens

DNA编码库筛选中的挑战和机遇

Basilius Sauter,Pinwen Cai,Koder Dagher et al.

Chimia. 2025 Mar 26;79(3):158-161. DOI:10.2533/chimia.2025.158

Reversible Covalent Reactions of Aldehydes and Salicylaldehydes Using a Lysine-Model Substrate

使用赖氨酸模拟底物进行的甲醛和水杨醛的可逆共价反应

Cécile Delmas,Emine Sager,Chrystele Henry et al.

Chimia. 2025 Mar 26;79(3):152-157. DOI:10.2533/chimia.2025.152

Precision Probing of O-GalNAc Glycosylation Using Bump-and-Hole Engineering

使用突起与孔洞工程精确探测O-甘露糖酰化

Abdul Zafar,Benjamin Schumann

Chimia. 2025 Mar 26;79(3):146-151. DOI:10.2533/chimia.2025.146

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