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Development of a Scalable Synthetic Route to (1 R,5 R)-2,2-Dimethoxybicyclo[3.1.0]hexan-3-one: An Important Intermediate in the Synthesis of Lenacapavir

(lenacapavir合成中的)重要中间体(1R,5R)-2,2-二甲氧基双环[3.1.0]己烷-3-酮的可扩展合成路线的开发

Aline Nunes De Souza,Nagaraju Sakkani,Daryl Guthrie et al.

Organic process research & development. 2025 Feb 26;29(3):846-855. DOI:10.1021/acs.oprd.4c00527

Impact of Reactant Dissolution in the Kinetics of a Catalytic Hydrogenation for the Production of Argatroban

反应物溶解对催化氢化生产阿加曲班的 kinetics 的影响

Filippo Nanto,Dario Ciato,Mariano Stivanello et al.

Organic process research & development. 2025 Mar 12;29(3):735-747. DOI:10.1021/acs.oprd.4c00479

Scaling Up Gas-Liquid Photo-Oxidations in Flow Using Rotor-Stator Spinning Disc Reactors and a High-Intensity Light Source

使用高强光源和转盘搅拌反应器在流动体系中扩大气液光氧化的规模

Arnab Chaudhuri,Wouter F C de Groot,Jasper H A Schuurmans et al.

Organic process research & development. 2025 Jan 14;29(2):460-471. DOI:10.1021/acs.oprd.4c00458

Flash Thermal Racemization of Chiral Amine in Continuous Flow: An Exploration of Reaction Space Using DoE and Multivariate Transient Flow

连续流动中手性胺的闪蒸热外消旋化：使用实验设计和多变量瞬态流探索反应空间

Matthew J Takle,Linden Schrecker,Benjamin J Deadman et al.

Organic process research & development. 2025 Feb 11;29(2):545-554. DOI:10.1021/acs.oprd.4c00508

Characterization of Amorphous Ibrutinib Thermal Stability

阿布鲁丁布的无定形形式及其热稳定性研究

Dan Trunov,Jan Ižovský,Josef Beranek et al.

Organic process research & development. 2025 Jan 7;29(1):56-65. DOI:10.1021/acs.oprd.4c00299

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