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The Discovery and Preclinical Pharmacology of JNJ-10450232 (NTM-006), a Centrally Penetrant, Non-Opioid Structural Analog of Acetaminophen with Comparable Analgesic and Anti-Pyretic Properties but No Evidence of Hepatotoxicity

JNJ-10450232（NTM-006）的发现及其药理学研究：一种可穿透中枢系统的非阿片类对乙酰氨基酚衍生物，具有相当的镇痛和解热特性且无肝毒性证据

Christopher M Flores,John R Carson,Ellen E Codd et al.

Regulatory toxicology and pharmacology : RTP. 2025 Apr 11:105830. DOI:10.1016/j.yrtph.2025.105830

Reproductive and developmental toxicity screen (OECD TG 421) and extended one generation reproductive toxicity study (OECD TG 443) of decahydronaphthalene in Sprague Dawley rats

十氢化萘对Sprague Dawley大鼠的生殖发育毒性筛选（ OECD TG 421）及跨三代动物繁殖试验（OECD TG 443）

John M Rogers,Melissa M Heintz,Laurie C Haws

Regulatory toxicology and pharmacology : RTP. 2025 Apr 11:105829. DOI:10.1016/j.yrtph.2025.105829

Human Health Risk Assessment for Exposures to 1,3-Butadiene in the United States with Input from an Independent Science Advisory Panel

美国1,3-丁二烯人体健康风险评估及独立专家科学咨询委员会的意见

C R Kirman,G Boysen,M J DiNovi et al.

Regulatory toxicology and pharmacology : RTP. 2025 Apr 7:105819. DOI:10.1016/j.yrtph.2025.105819

Report of the European Commission Workshop on "The Roadmap Towards Phasing Out Animal Testing for Chemical Safety Assessments", Brussels, 11-12 December 2023

欧盟委员会关于“迈向淘汰化学品安全评估中动物试验路线图的工作组会议”报告布鲁塞尔，2023年12月11-12日

Mark T D Cronin,Elisabet Berggren,Sofia Camorani et al.

Regulatory toxicology and pharmacology : RTP. 2025 Apr 4:105818. DOI:10.1016/j.yrtph.2025.105818

Preclinical safety studies of a SEDDS formulation of the vasorelaxing methanol extract from Crataegus rosei Eggl. leaves

山楂叶提取物体外 vasorelaxing SEDDS 制剂的临床前安全性研究

Diana López-Fitz,Moustapha Bah,Carlos Tomás Quirino-Barreda et al.

Regulatory toxicology and pharmacology : RTP. 2025 Mar 29:105815. DOI:10.1016/j.yrtph.2025.105815

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