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Scalable process development for rAAV transient transfection production using computational fluid dynamics modeling

基于计算流体动力学建模的rAAV瞬时转染生产可扩展工艺开发

Jianfa Ou,Yawen Tang,Alexander Williams et al.

Biotechnology progress. 2025 Apr 4:e70028. DOI:10.1002/btpr.70028

N-1 semi-continuous transient perfusion in shake flask for ultra-high density seeding of CHO cell cultures in benchtop bioreactors

用于台式生物反应器中高密度接种的CHO细胞培养摇瓶中的N-1半连续灌流

Lucas Lemire,Sebastian-Juan Reyes,Yves Durocher et al.

Biotechnology progress. 2025 Apr 3:e70029. DOI:10.1002/btpr.70029

Continuous glucose feedback control using Raman spectroscopy and deep learning models for biopharmaceutical processes

基于拉曼光谱和深度学习模型的连续血糖反馈控制用于生物制药过程

Mohammad Rashedi,Matthew Demers,Hamid Khodabandehlou et al.

Biotechnology progress. 2025 Apr 2:e70020. DOI:10.1002/btpr.70020

Cryopreservation practices in clinical and preclinical iPSC-based cell therapies: Current challenges and future directions

基于诱导多能干细胞的临床和非临床细胞治疗中的冷冻保存实践：当前挑战与未来方向

Michael Dobruskin,Geoffrey Toner,Ronald Kander

Biotechnology progress. 2025 Apr 2:e70031. DOI:10.1002/btpr.70031

N-acetyl-D-mannosamine, a novel additive, effectively reducing high mannose glycosylation of monoclonal antibody without affecting other quality attributes

N-乙酰-D-岩藻糖胺，一种新型添加剂，在不影响其他质量属性的情况下有效降低单克隆抗体的高岩藻糖基甘露糖残基比例

Miaomiao Chai,Hai Shu,Qiancheng Wang et al.

Biotechnology progress. 2025 Apr 2:e70024. DOI:10.1002/btpr.70024

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