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SOX9-dependent fibrosis drives renal function in nephronophthisis

SOX9依赖性纤维化驱动肾小管萎缩-间质纤维化病的肾脏功能障碍

Maulin Mukeshchandra Patel,Vasileios Gerakopoulos,Bryan Lettenmaier et al.

EMBO molecular medicine. 2025 Apr 10. DOI:10.1038/s44321-025-00233-3

Clinically translatable mitochondrial gene therapy in muscle using tandem mtZFN architecture

一种临床可转化的肌肉细胞线粒体基因疗法及其串联型mtZFN结构

Pavel A Nash,Keira M Turner,Christopher A Powell et al.

EMBO molecular medicine. 2025 Apr 9. DOI:10.1038/s44321-025-00231-5

A decisive technical leap forward for personalized medicine to treat mitochondrial diseases

个性化治疗线粒体疾病医学的决定性技术飞跃

Abi S Ghifari,Martin Ott

EMBO molecular medicine. 2025 Apr 9. DOI:10.1038/s44321-025-00232-4

Proteomics and personalized PDX models identify treatment for a progressive malignancy within an actionable timeframe

蛋白质组学和个性化PDX模型在可操作的时间范围内识别出了治疗进行性恶性肿瘤的药物

Georgina D Barnabas,Tariq A Bhat,Verena Goebeler et al.

EMBO molecular medicine. 2025 Apr;17(4):625-644. DOI:10.1038/s44321-025-00212-8

Generalization of neoantigen-based tumor vaccine by delivering peptide-MHC complex via oncolytic virus

通过溶瘤病毒递送肽-MHC复合物来基于新抗原的肿瘤疫苗的通用性增强研究

Chenyi Wang,Yingjun Shi,Da Zhang et al.

EMBO molecular medicine. 2025 Apr 7. DOI:10.1038/s44321-025-00225-3

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