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Osteopontin attenuates the foreign-body response to silicone implants

骨桥蛋白减轻对硅胶植入物的异物反应

Michelle F Griffin,Jennifer B Parker,Ruth Tevlin et al.

Nature biomedical engineering. 2025 Mar 24. DOI:10.1038/s41551-025-01361-4

Cas12a-knock-in mice for multiplexed genome editing, disease modelling and immune-cell engineering

用于多重基因组编辑、疾病建模和免疫细胞工程的Cas12a敲入小鼠

Kaiyuan Tang,Liqun Zhou,Xiaolong Tian et al.

Nature biomedical engineering. 2025 Mar 20. DOI:10.1038/s41551-025-01371-2

A deep-learning model for quantifying circulating tumour DNA from the density distribution of DNA-fragment lengths

用于通过DNA片段长度的分布密度定量循环肿瘤DNA的深度学习模型

Guanhua Zhu,Chowdhury Rafeed Rahman,Victor Getty et al.

Nature biomedical engineering. 2025 Mar 7. DOI:10.1038/s41551-025-01370-3

Non-viral intron knock-ins for targeted gene integration into human T cells and for T-cell selection

用于人类T细胞靶向基因整合和T细胞选择的非病毒型内含子敲入技术

Theodore L Roth,Johnathan Lu,Alison McClellan et al.

Nature biomedical engineering. 2025 Mar 7. DOI:10.1038/s41551-025-01372-1

Identifying perturbations that boost T-cell infiltration into tumours via counterfactual learning of their spatial proteomic profiles

通过反事实学习肿瘤空间蛋白质谱来识别促进T细胞浸润的扰动因素

Zitong Jerry Wang,Abdullah S Farooq,Yu-Jen Chen et al.

Nature biomedical engineering. 2025 Mar 5. DOI:10.1038/s41551-025-01357-0

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