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ACS Chemical Neuroscience发表高质量的化学、定量生物学、生物物理和生物工程方法研究等方向的论文和综述，其中也包含以了解神经系统并开发神经系统疾病的新疗法等内容。该期刊主要研究化学神经生物学和生物神经化学等领域，同时也欢迎将遗传模型系统与计算生物学、影像学、电生理学和计算神经科学（神经信息学）等结合使用的研究成果。
期刊收录研究方向：神经递质和受体，神经药物和治疗，神经发育-可塑性和变性，神经科学中的化学、物理和计算方法，神经元疾病-基础、检测和治疗，衰老、学习、记忆和行为的机制，疼痛和感觉过程，神经毒素，受神经科学启发的生物工程，化学神经生物学方法的发展，神经成像剂和技术，中枢神经系统疾病的动物模型，行为研究
ACS Chemical Neuroscience publishes high-quality research articles and reviews that showcase chemical, quantitative biological, biophysical and bioengineering approaches to the understanding of the nervous system and to the development of new treatments for neurological disorders. Research in the journal focuses on aspects of chemical neurobiology and bio-neurochemistry such as the following:
Neurotransmitters and receptors
Neuropharmaceuticals and therapeutics
Neural development—Plasticity, and degeneration
Chemical, physical, and computational methods in neuroscience
Neuronal diseases—basis, detection, and treatment
Mechanism of aging, learning, memory and behavior
Pain and sensory processing
Neurotoxins
Neuroscience-inspired bioengineering
Development of methods in chemical neurobiology
Neuroimaging agents and technologies
Animal models for central nervous system diseases
Behavioral research
